Amyloidosis in Retinal Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Amyloidosis in Retinal Neurodegenerative Diseases
As a part of the central nervous system, the retina may reflect both physiological processes and abnormalities related to pathologies that affect the brain. Amyloidosis due to the accumulation of amyloid-beta (Aβ) was initially regarded as a specific and exclusive characteristic of neurodegenerative alterations seen in the brain of Alzheimer's disease (AD) patients. More recently, it was discov...
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Most neurodegenerative diseases share several clinical, genetic and pathophysiological features, and an irreversible evolution as well. They are characterized by an endogenous production of abnormal proteins called amyloid proteins (AP), which are not hydrosoluble, form depots, and are only partly cleared by autophagy and the ubiquitin-protease system. Despite their different structures, they a...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2016
ISSN: 1664-2295
DOI: 10.3389/fneur.2016.00127